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生醫工程研究中心
Tissue Engineering Research Group
Ø          Publication:
A. Journal Papers
l          S.S.Hung, Zhon-Liau Lee and M.Y.Lee, 2008,” Clinical Application of Rapid Prototype Model in Pediatric Proximal Femoral Corrective Osteotomy”, Journal of ORTHOPEDICS, Vol.31, No.1, pp.1~5, January 2008
l          Liaw, J-W., Tsai, S-W., Chen, K-L. and Hsu F-Y. (2010) "Single-photon and Two-photon Cellular Imagings of Gold Nanorods and Dyes" Journal of Nanoscience and Nanotechnology (in press) 
l          Tsai,S-W., Chen, C-C., Liu, H-M and Hsu, F-Y. (2009) “Preparation and characterization of microspheres comprised of collagen, chondroitin sulfate and apatite as carriers for the osteoblast-like cell MG63” J. Biomed. Mater. Res. Part A. DOI: 10.1002/jbm.a.32502
l          Tsai,S-W., Chen C-C., Chen, P-L. and Hsu, F-Y. (2009) “Influence of topography of nanofibrils of three-dimensional collagen gel beads on the phenotype, proliferation, and maturation of osteoblasts” J. Biomed. Mater. Res. Part A 91A: 985-993.
l          Tsai, S-W., Liaw, J-W., Hsu, F-Y., Chen,Y-Y. Lyu, M-J and Yeh, M-H. (2008) “Surface-Modified Gold Nanoparticles with Folic Acid as Optical Probes for Cellular Imaging” Sensors (8): 6660-6673 
l          Tsai, S-W., Hsu, F-Y. and Chen, P-L. (2008) “Beads of collagen–nanohydroxyapatite composites prepared by a biomimetic process and the effects of their surface texture on cellular behavior in MG63 osteoblast-like cells” Acta Biomaterialia 4 :1332–1341
l           Tsai,S-W., Chen,Y-Y. and Liaw, J-W.(2008) “Compound Cellular Imaging of Laser Scanning Confocal Microscopy by Using Gold Nanoparticles and Dyes”, Sensors (8): 2306-2316
l          Fang, J. Y., Fang, C. L. , Liu, C. H., Su, Y. H., Lipid nanoparticles as vehicles for topical psoralen delivery: Solid lipid nanoparticles (SLN) versus nanostructured lipid carriers (NLC), European Journal of Pharmaceutics and Biopharmaceutics 70, 633-640
l          Ho, Y. C., Liu, C. H., Chen, C. N., Duan, K. J., Lin, M. T. 2008, Inhibitory effects of xanthohumol from hops (Humulus lupulus L.) on human hepatocellular carcinoma cell lines, Phytotherapy Research, 22, 1465–1468.
l          C. H. Liu, K. W. Wu. 2009. Synergistic effects of basic fibroblast growth factor and insulin on Chinese hamster ovary cells under serum-free conditions. J. Bioscience and Bioengineering, 2009, 107(3), 312-317.
l          C. H. Liu, C. T. Wu. 2010. Optimization of nanostructured lipid carriers for lutein delivery. Colloids and Surfaces A: Physicochem. Eng. Aspects, 2010, 353(1) 149-156.
l          C. H. Liu, C. T. Wu, J.Y. Fang. 2009. Characterization and formulation optimization of solid lipid nanoparticles in vitamin K1 delivery. Drug Development and Industrial Pharmacy, (In press)
l          Wu, M. H., Huang, S. B., Lee, G. B. 2009. “Microfluidic cell culture systems for drug research” Lab on a Chip, In press (SCI, IF: 6.478, 4/65: Biochemical Research Methods) (Invited Review Paper)
l          Wu, M. H.* and Pan, W. C. 2009. “Development of microfluidic alginate microbead generator tunable by pulsed airflow injection for the microencapsulation of cells”, Microfluidics and Nanofluidics, In press (SCI, IF: 3.314, 4/56: Instruments & Instrumentation) 
l          Wu, M. H., Lin, J. L., Wang, J., Cui, Z. F., Cui, Z. 2009. “Development of high throughput optical sensor array for on-line pH monitoring in micro-scale cell culture environment,” Biomedical Microdevices 11, 265-273.
l          Wu, M. H.* 2009. “Simple poly(dimethylsiloxane) surface modification to control cell adhesion,” Surface and Interface Analysis 41, 11-16
l          Huang, S. B., Wu, M. H., Lee, G. B. 2009. A tunable micro filter modulated by pneumatic pressure for cell separation. Sensors and Actuators B, 142, 389-399.
l          Wu, M. H., Huang, S. B., Cui, Z. F., Cui, Z., Lee, G. B. 2008. “A high throughput perfusion-based microbioreactor platform integrated with pneumatic micropumps for three-dimensional cell culture,” Biomedical Microdevices 10, 309-319.
l          Wu, M. H., Huang, S. B., Cui, Z. F., Cui, Z., Lee, G. B. 2008. “Development of perfusion-based micro 3-D cell culture platform and its application for high throughput drug testing,” Sensors and Actuators B 129, 231-240.
l          Huang, S. B., Wu, M. H., Cui, Z. F., Cui, Z., Lee, G. B. 2008. “A membrane-based serpentine-shape pneumatic micropump with pumping performance modulated by fluidic resistance,” Journal of Micromechanics and Microengineering 18, 045008 (12 pp).
l          Ma, D.H.-K., Chen, H.-C., Lai, J.-Y., Sun, C.-C., Wang, S.-F., Lin, K.-K., Chen, J.-K.. (2009). Matrix revolution: molecular mechanism for inflammatory corneal neovascularization and restoration of corneal avascularity by epithelial stem cell transplantation. Ocular Surface, 7, 128-144.
l          Lai, J.-Y. 2009. The role of Bloom index of gelatin on the interaction with retinal pigment epithelial cells. International Journal of Molecular Sciences, 10, 3442-3456.
l          Chen, H.-C., Chen, H.-L., Lai, J.-Y., Chen, C.-C., Tsai, Y.-J., Kuo, M.-T., Chu, P.-H., Sun, C.-C., Chen, J.-K., Ma, D.H.-K. Persistence of transplanted oral mucosal epithelial cells in human cornea. Investigative Ophthalmology & Visual Science, 50, 4660-4668.
l          Lai, J.-Y., Hsiue, G.-H.. 2010. Corneal endothelial reconstruction with a bioengineered cell sheet. Book Chapter In: Corneal Endothelial Transplant DSAEK, DMEK & DLEK (John, T., Ed.), Page 405-420.
l          Lai, J.-Y.*, Lin, P.-K., Hsiue, G.-H., Cheng, H.-Y., Huang, S.-J., Li, Y.-T. (2009) “Low Bloom strength gelatin as a carrier for potential use in retinal sheet encapsulation and transplantation”, Biomacromolecules, 10(2), 310-319.
l          Lu, P.-L., Lai, J.-Y. (Equal First Author), Ma, D.H.-K., Hsiue, G.-H. (2008) “Carbodiimide cross-linked hyaluronic acid hydrogels as cell sheet delivery vehicles: characterization and interaction with corneal endothelial cells”, J. Biomater. Sci.-Polym. Ed., 19(1), 1-18. 
l          Ma, D.H.-K., Sun, A.C.-C., Lai, J.-Y., Chen, J.-K. (2008) “A review of corneal epithelial stem cell therapy”, In: Progress in Stem Cell Applications (Faraday, A.V., Dyer, J.T., Eds.), Nova Science Publishers, New York, pp. 13-56. [Invited Book Chapter]
l          J.P. Chen, S.F. Li and Y.P. Chiang. 2010. Bioactive collagen-grafted poly-L-lactic acid nanofibrous membrane for cartilage tissue engineering. Journal of Nanoscience and Nanotechnology, in press.
l          Y.T. Chen, S.H. Fu, J.P. Chen, and B.R.S. Hsu. 2009. AMT, an Inducible Nitric Oxide Synthase Inhibitor, Enhances Islet Engraftment. Transplantation Proceedings, 41, 1786–1788.
l          Y.H. Ma, S.Y. Wu, T. Wu, Y.J. Chang, M.Y. Hua, J.P. Chen*. 2009. Magnetically targeted thrombolysis with recombinant tissue plasminogen activator bound to polyacrylic acid-coated nanoparticles. Biomaterials, 30, 3343-3351.
l          B.R. Huang, P.Y. Chen, C.Y. Huang, S.M. Jung, Y.H. Ma, T. Wu, J.P. Chen,* K.C. Wei.2009. The bioavailability of magnetic nanoparticles to the brain. Journal of Magnetism and Magnetic Materials, 321, 1604-1609.
l          L.B. Jeng, H.Y. Chung, T.M. Lin, J.P. Chen, Y.L. Chen, Y.L. Lu, Y.J. Wang, and S.C.N. Chang. 2009. Characterization and osteogenic effects of mesenchymal stem cells on microbeads composed of hydroxyapatite nanoparticles/reconstituted collagen. Journal of Biomedical Materials Research, 91, 886-893.
l          J.P. Chen and T.H. Cheng. 2009. Preparation and evaluation of thermo-reversible copolymer hydrogels containing chitosan and hyaluronic acid as injectable cell carriers. Polymer, 50, 107-116.
l          J.P. Chen, and T.F. Yang. 2008. Applications of chitosan-based thermo-sensitive copolymers for harvesting living cell sheet. Applied Surface Science, 255, 297-300.
l          J.P. Chen and W.L. Lee. 2008. Collagen-grafted temperature-responsive nonwoven fabric for wound dressing. Applied Surface Science, 255, 412–415.
l          J.Y. Fang, J.P. Chen, Y.L. Leu and J.W. Hu. 2008. The delivery of platinum drugs from thermosensitivve hydrogels containing different ratios of chitosan. Drug Delivery, 15, 235-243.
l          J.Y. Fang, J.P. Chen, Y.L. Leu and J.W. Hu. 2008. Temperature-sensitive hydrogels composed of chitosan and hyaluronic acid as injectable carriers for drug delivery. European Journal of Pharmaceutics and Biopharmaceutics, 68, 626-636.
l          J.P. Chen and T.H. Cheng. 2008. Functionalized temperature-sensitive copolymer for tissue engineering of articular cartilage and meniscus. Colloids and Surfaces A: Physicochem. Eng., 313-314, 254-259.
l          J.P. Chen, G.Y. Chang, J.K. Chen. 2008. Electrospun collagen/chitosan nanofibrous membrane as wound dressing. Colloids and Surfaces A: Physicochem. Eng. Aspects, 313-314, 183-188.
A. Conference Papers
l          Chih-Feng Lin, Kok-Soon Soon, Ming-Yih Lee,”The Influence of Sensory Disturbance on Postural Control During Spin Turn 180°,”2nd International Convention on Rehabilitation Engineering & Assistive Technology (i-CREATe 2008), Bangkok, Thailand, 13-15 May 2008. 
l          Lin, C-J.; Tsai, S-W.; Hsu, F-Y. (2009)” Influence of molecular-scale topography of collagen and gelatin electrospun fibrous on the phenotype and proliferation of MG63 osteoblast-like cells” ICMAT & IUMRS-ICA, June, Singapore
l          Tsai, S-W., Chen, P-R., Li, Z-R. and Hsu, F-Y.(2008) “Fabrication of a 3D biomimic bone matrix and investigation the effects on the MG63 cellular behaviors” 8th World Biomaterials Congress, May
l          Liaw,J-W., Chen, Y-Y., Hsu,F-Y. and Tsai,S-W. (2008)” Surface modification of gold nanoparticles for the application of cellular imaging” 8th World Biomaterials Congress, May.
l          Wu, M. H., Pan, T. M., Cheng, C. H., Liao, K. M. 2008. “Structural properties of high-k PrTiO3 sensing film and its application for ISFET-based pH sensing” MNE 2008 (34th International Conference on Micro and Nano Engineering), Athens, Greece.
l          Huang, S. B., Wu, M. H., Cui, Z. F., Cui, Z., Lee, G. B. 2008. “Development of microfluidic based 3-dimensional cell culture platform and its application for high-throughput drug testing” MNHT 2008 (Micro/Nanoscale Heat Transfer International Conference), Tainan, Taiwan.
l          Lai, J.-Y., Hsiue, G.-H. (2009) “Functional biomaterials for corneal endothelial cell therapy and regenerative medicine”, Biomaterials Asia 2009, Apr. 5-8, Hong Kong. [Invited Lecture]
l          Tu, J.-D., Lai, J.-Y., Hsiue, G.-H. (2008) “Tissue-engineered human corneal endothelial cell sheet transplantation using functional biomaterials”, 2008 Annual Conference of Tissue Engineering and Regenerative Medicine International Society-Asian Pacific Region, Nov. 6-8, Taipei, Taiwan, ROC. [Best Poster Paper Award]
l          Lai, J.-Y., Hsiue, G.-H. (2008) “Functional biomedical polymers for corneal cell therapy and regenerative medicine”, 42nd IUPAC World Polymer Congress, Jun. 29-Jul. 4, Taipei, Taiwan, ROC. [Contributed Lecture]
l          Lai, J.-Y., Lu, P.-L., Hsiue, G.-H. (2008) “Bioengineered human corneal endothelial cell sheet transplantation using functional biomaterials”, 8th World Biomaterials Congress, May 28-Jun. 1, Amsterdam, Netherlands. [Contributed Lecture]
l          Lai, J.-Y., Lu, P.-L., Hsiue, G.-H. (2008) “Gelatin hydrogels as multifunctional carriers for cell sheet delivery in corneal tissue engineering applications”, 8th World Biomaterials Congress, May 28-Jun. 1, Amsterdam, Netherlands. [Contributed Lecture]
l          Lai, J.-Y., Hsiue, G.-H. (2008) “Functional biomedical polymers for ocular regenerative medicine”, 31st ROC Polymer Symposium, Jan. 18-19, Hsinchu, Taiwan, ROC. [Invited Lecture]
l          J.P. Chen, S.F. Li. 2008. Bioactive collagen-grafted PLLA nanofibrous membrane for cartilage tissue engineering. Annual Conference of Tissue Engineering and Regenerative Medicine International Society - Asian Pacific Region, Taipei, Taiwan. (invited lecture)
l          J.P. Chen, G.Y. Chang and Y.C. Tong. 2008. Production of bioactive nanofibrous membranes by electrospinning for applications as wound dressings. 2008. Taiwan/ Korea/Japan Chemical Engineering Conference, Taipei, Taiwan. (invited lecture)
l          J.P. Chen and S.C. Chen. 2008. Application of thermo-sensitive hydrogel in hepatic tissue engineering. 13th International Biotechnology Symposium, Dalian, China. Journal of Biotechnology, 136S, S124. (SCI)
l          J.P. Chen and T.H. Cheng. 2008. Bone regeneration using 3D hyaluronic acid and chitosan containing thermo-reversible hydrogel and canine mesenchymal stem cells. 13th International Biotechnology Symposium, Dalian, China. Journal of Biotechnology, 136S, S128-S129. (SCI)
l          C.H. Lu and J.P. Chen. 2008. Bioactive electrospun silver nanoparticles-containing polyurethane nanofibers as wound dressings. Materials Research Society International Materials Research Conference, Chongqing, China.
l          Y. Chiang and J.P. Chen. 2008. Synthesis of thermo-responsive hyaluronic acid based hydrogel and its application in cartilage tissue engineering using mesenchymal stem cells. Materials Research Society International Materials Research Conference, Chongqing, China.
l          J.P. Chen and T.H. Cheng. 2008. Preparation and evaluation of thermo-reversible chitosan-g-poly(N-isopropylacrylamide) (CPN) and hyaluronic acid-g-CPN copolymers as injectable cell carriers. Materials Research Society 2008 Spring Meeting, San Francisco, USA.
l          C. H. Liu and K. H. Chang. 2008. Molecular cloning and characterization of a thermostable lipase from plant Carica papaya. The Society for Biotechnology, Japan 2008 Annual Meeting.
l          C. H. Liu and C. C. Wen. 2009. Benzyl alcohol and its esters enhance recombinant protein expression in Chinese hamster ovary cells,. The Society for Biotechnology, Japan 2009 Annual Meeting.
Ø          Patents:
l          M.Y.Lee et al, Layer-based laser source construction for rapid prototyping machine, ROC Invention patent # I268213.
l          M.Y.Lee et al, Layer-based coating motion control mechanism for liquid resin rapid prototyping machine, ROC New-utility patent #M282753.
l          M.Y.Lee et al, Injection nozzle cleaning device for liquid resin rapid prototyping machine, ROC New-utility patent #M262124.
l          M.Y.Lee et al, Layer-based laser source construction for rapid prototyping machine, ROC Invention patent # I299693.
l          S.W. Tsai et al., Water-insoluble,crosslinked-polysaccharides (US patent 6852255)
l          Liu, C. H., Liao, C. C. 2000, Microorganisms and process for fermented black tea beverage (Japan Patent 3084348)
l          “Perfused Microbioreactor”, Patents application in process (EP1799806,  WO 2006032863, GB0420881D), Inventors: Wu, M. H., Xu, X., Cui, Z. F.
l          “Apparatus And Method For High Throughput Micro Cell Culture With Mechanical Stimulation” Wu, M.H., Pan, W.C. Kuo, C.Y. US patent application (Patent filing No. 12/437803, Filing date: 2008/5/8)
l           
Ø          Awards:
l          M.Y.Lee, Gold medals in Nuremberg International Invention exhibition (Germany) , 1998-2000
l          M.Y.Lee, Best PI of National Education Resource Center, Ministry of Education, Taiwan, 2006
l          M.Y.Lee, Various Best paper awards (e.g. SME, Robotics/Mechanism, Biomedical Engineering Conferences), 1995-2008